It seems that these are two (three?) independent problems by three different people.

In my case the train network is a simple grid with all stations available from all stations (and all rails working one-direction).

I cannot attach the save as it is 240 MB big... The problem regards only two ...

I've just updated to 2.0.10 and the problem is still there. Also it seems that sometimes the train colors change when I change the mode between automatic and manual. Something is definitely wrong...

I rerouted all the involved trains to other schedules. And after a couple of hours of gameplay the ...

I have the same problem, the trains show alert "Train cannot find path to destination.". When I click on the train and hover over the next station, the hint says "All 11 stops are inaccessible from current position.". However, such trains sometimes depart once a free place occurs in one of the ...