I'm not sure I can recreate it. Sure its not much you can do developer-wise when there's no ram or HD space left over, but I thought it was interesting to note.

Here's what my console logs say at the time of glitching:
13/12/2014 22:41:03.734 com.apple.mtmd: attempting to thin because of low free space on Macintosh HD (/) by removing 2014-12-13 22:18:11 +0000
13/12/2014 22:44:10.659 factorio: NSMapGet: map table argument is NULL